smart immuno FOB Test
Summary
The presence of hemoglobin in feces is indicative of the presence of blood as a result of bleedings associated to some pathologies of the gastrointestinal tract (Fecal Occult Blood, FOB). Such pathologies are colon polyps, adenomas, colorectal carcinoma, ulcerative colitis and Crohn' disease. Colorectal cancer (CRC) is the third most common form of cancer in western world. CRC often causes no symptoms until it has reached a relatively advanced stage. Thus, many organizations recommend screening for the disease with FOB-testing.
Colorectal bleeding can be sometimes intermittent and so negative results do not exclude the disease. Colonoscopy is recommended as definitive test. This method is worthless as screening test for diseases of the upper-gastrointestinal tract.
Methode Analytical Range
Linearity: up to 1000 µg/l. Linearity limit depends on the sample/reagent ratio as well as the calibrator value Samples with higher concentrations should be diluted 1:5 with NaCl 9 g/l and retested again. Lower detection limit: Values < 25 µg/l give non-reproducible results.
Principle
The latex particles coated with antibodies anti-human hemoglobin are agglutinated when they react with feces samples containing human hemoglobin. Photometric measurement at 546nm or 700nm.
Test Duration
Test duration takes approx. 5 minutes
Package Insert
More details can be found in the package insert and the additional package insert for the sample collection.
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