Summary and explanation:

Lipoprotein(a), Lp(a), is a low density lipoprotein like particle containing apolipoprotein B-100 disulphide-linked to the large glycoprotein called apoplipoprotein (a). The characteristic feature of Lpa is that it is distinct from all other serum proteins and apolipoproteins. This protein is believed. this protein is believed to be inherited as an autosomal dominant trait and appears to be insensitive to either diet, lifestyle or most hypolipidaemic drugs. Since its discovery by BERG in 1963 there has been a considerable rise in interest not only in specialised research centers but also in clinical laboratories in the accurate measurement of Lp(a) in blood.
This interest was stimulated by reports indicating that levels above 20-30mg/dl present in approx 25% of the population are associated with an increased risk of coronary heart disease.. Many investigators have confirmed that high Lp(a) concentrations represents an indicator of risk for cardiovascular disease, especially when serum LDL or APO B are elevated.
Therefore a convenient and reliable method for the quantification of Lpa in serum or plasma is important for identification of individuals at risk for developing arteriosclerosis.

Methode Analytical Range:

Lpa Antigen+AntiLpa Antibodies > Antigen Antibody comples Serum: 1-80 mg/dl

Principle:

Kinetic measurement of the Lp(a) concentration at 700nm (Absorbance)