smart PT (INR) coagulation test
Summary
During oral anticoagulant therapy most of the Vitamin K dependent factors such as II, VII, IX, X, Protein C and Protein S are depressed, as also during the deficiencies of clotting factor activity which may be hereditary or acquired. Prothrombin time determination is the preferred method for pre-surgical screening, as a liver function test, determination of congenital deficiency of factors II, V, VII, and X ans for monitoring of patients on oral anticoagulant therapy.
Interferences of the Test
The PT may be shortened during acute inflammatory conditions which are accompanied by increase in Fibrinogen levels and also by agents such as antihistamines, butabarbital, phenobarbital, caffeine, orcal contraceptives and vitamin K. The PT may be prolonged by corticosteroids, EDTA, asparaginase, clofibrate, erythromycin, ethanol, tetracycline, aspirin and anticoagulants such as heparin and warfarin.
Method Analytical Range
Measuring Range: 1 - 6 INR
Recombinant
ISI: 1,0 - 1,18 (LOT pending)
Principle
Photometric detection of a solid gel clot within a specified period of time
Test Duration
Test duration takes approx. 2:30 minutes at INR = 1.
Package Insert
More details can be found in the package insert.
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