solo SAA Test
Summary
Serum Amyloid A (SAA) is an early and sensitive blood biomarker for tissue injury and inflammation and has been indicated in many inflammatory diseases. The level of SAA circulating in the blood is known to increase dramatically in response to tissue damage or inflammation, classifying it as an acute phase protein. Circulating SAA concentrations may increase up to 1000-fold following inflammation, infection, tissue injury and cell necrosis and decline rapidly following recovery. It has also been observed in several veterinary species including the horse that SAA is a very useful inflammatory marker that may be used for detection of clinical and possibly subclinical disease, monitoring of disease activity and response to therapy, prognostication, and detection of spread of infections in herds (Nielsen et al., 2004). The kinetic profile of the SAA response makes SAA an excellent indicator of inflammation. Hepatic SAA synthesis begins shortly after an inflammatory insult. As a result plasma concentrations start to increase within few hours, and they peak 3648 h after injury, as demonstrated previously in horses after experimental induction of inflammatory or infectious disease(HulteŽn et al., 2002).
Assay principle
Latex agglutination test based on optical measurement of the change in turbidity caused by the agglutination of the latex particles sensitised with SAA antibodies.
Sample material
Use serum or plasma for routine analysis. In several cases milk and synovial fluids can be used for SAA detection as well.
Package insert
More details can be found in the package insert.
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