Eurolyser Diagnostics - Premium Laboratory Equipment

ASO test

Antistreptolysin O

About the parameter

Video


Eurolyser ASO Single Test Thumbnail

Antistreptolysin O (ASO) is an antibody targeted against streptolysin O, a toxic enzyme produced by group A streptococcus bacteria. Together with anti-DNase B, ASO is the most common of several antibodies produced by the human immune system in response to a strep infection with group A Streptococcus. Group A streptococcus (streptococcus pyogenes) is a bacterium causing strep throat and a variety of other infections, including skin infections (pyoderma, impetigo, cellulitis).

If diagnosed properly, most strep infections can be treated with antibiotics and the infections resolve. If, however, a strep infection does not cause identifiable symptoms, goes untreated, or is treated ineffectively, conditions such as rheumatic fever and the kidney disease glomerulonephritis can develop – especially in young children. Such conditions can cause serious complications such as damage the heart, acute kidney dysfunction, tissue swelling (edema) and high blood pressure (hypertension). The Eurolyser ASO test can be used to determine if such conditions/symptoms are due to a recent group A strep infection.

Overview

Method

Latex particles coated with Streptolysin O react with ASO in the patient sample resulting in an increase in turbidity, the absorbance is measured at 700 nm and is directly proportional to the concentration of ASO in the sample.
 

Measurement range

Latex enhanced immunturbidimetric assay, 100-2000 IU/ml

Reference range
≤ 100 IU/ml for preschool children
≤ 250 IU/ml for school age children
≤ 200 IU/ml for adults

It is recommended that each laboratory establishes its own expected range.
 

Test duration

The test takes approximately 10 minutes.
 

Package insert

More details can be found in the package insert.

Please note: All package inserts provided on this website are intended for information purposes only! Always process all tests, controls and calibrators strictly according to the package insert provided with the kit.


Appropriate instruments


Evaluation

Assay evaluation

Find the evaluation study for the Eurolyser ASO assay here: Evaluation Eurolyser ASO

 
Please note: depending on the time of the market launch of an assay, the respective assay evaluation was carried out using either a Eurolyser smart instrument or a Eurolyser CUBE instrument.

Since the measurement method is the same in both instruments (their photometric units are identical in construction), as was proved in this comparison study, all testkit evaluations provided on this website are valid for either instrument!


Additional information

Order numbers

ST 0250     ASO test kit (containing 16 tests)
ST 2500     ASO control kit (decision level)
 

Medical studies

Studies show that ASO testing is significantly more suitable to diagnose group A streptococci than blood cultures:

Anti-Streptolysin-O in comparism to positive blood culture in determining the prevalence of group A streptocuccus infection

ASO in microbial diagnosis of orthopedic infections


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