About the parameter
Homocysteine, often shortened to “HCY”, is a thiol containing amino acid produced by the intracellular demethylation of methionine. Excess HCY in the blood stream may cause injuries to arterial vessels due to its irritant nature and result in inflammation and plaque formation, which may eventually cause a blockage of blood flow to the heart.
Unhealthily elevated HCY levels are caused by four major factors:
- genetic deficiencies
- nutritional deficiency in B vitamins such as B6, B12 and folate
- renal failure for effective amino acid clearance
- drug interactions such as niacin, methotrexate and phenytoin
High levels of HCY are generally associated with peripheral arterial occlusive disease, strokes, coronary heart conditions (angina pectoris, heart attack), tightening of the carotid artery and with extremely elevated leves also to Alzheimer’s disease and osteoporosis.
Kinetic determination of HCY concentration through photometric absorbance measurement at 340 nm, based on the enzymatic cycling method.
Serum: 3 – 50 µmol/l (small, lot specific variations possible)
Test duration takes approx. 11 minutes.
More details can be found in the package insert.
Please note: All package inserts featured on this website are intended for information purposes only! Always process all tests, controls and calibrators strictly according to the package insert provided with the kit.
Find the evaluation study for the Eurolyser Homocysteine assay here: Evaluation Eurolyser Homocysteine
Please note: depending on the time of the market launch of an assay, the respective assay evaluation was carried out using either a Eurolyser smart instrument or a Eurolyser CUBE instrument.
Since the measurement method is the same in both instruments (their photometric units are identical in construction), as was proved in this comparison study, all testkit evaluations provided on this website are valid for either instrument!
ST 0120 Homocysteine test kit (containing 16 tests)
ST 1200 Homocysteine control kit (low/high)
More information about homocysteine can be found in this YouTube video.